Pain Science RA 3 Practice

Gabapentinoids commonly cause central nervous system side effects, with sedation and dizziness being the most frequently reported. They work by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the CNS, which reduces the release of excitatory neurotransmitters and dampens neural activity. This mechanism explains the common feelings of sleepiness and unsteadiness, especially when starting treatment or after dose changes, and why caution is advised with activities requiring alertness. Hypertension is not typically linked to these drugs, increased energy is not expected, and while some patients may experience weight gain, sedation and dizziness are the most characteristic and consistent effects.